The 158-seater C919 aircraft took to the skies from Shanghai Pudong International Airport in eastern China and made the country the fourth jumbo jet producer after the US, Europe and Russia, the state media reported.
The 80-minute flight was greeted with applause by more than 1,000 spectators on the tarmac, including Chinese Vice Premier Ma Kai and Shanghai Party chief Han Zheng.
The twin-engine plane departed with five crew members on board but without any passengers.
The "C" in the aircraft's name stands for both China and COMAC, while 9 symbolises "forever" in Chinese culture and 19 represents the maximum 190 seats capacity.
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With a standard range of 4,075 kilometres, the narrow- body jet is comparable with updated Airbus 320 and Boeing's new generation 737, signalling the country's entry into the global aviation market, Xinhua news agency reported.
China in recent times has been making big breakthroughs in aviation with new fighter aircraft, including a stealth aircraft, but this is the first time it came out with a passenger plane.
China's first amphibious aircraft, stated to be the largest in the world,successfully conducted its first glide test on April 29 in Chinese city of Zhuhai and braced for its maiden flight.
China began to develop its own jumbo passenger jets in the 1970s and the first one, the Y-10, had a successful test flight in 1980. But the project was abandoned later.
Theplanepassed expert technical appraisal this March.
The aircraft was given the go-ahead in April to begin a series of high-speed taxiing tests, the final step before its maiden flight. More than 200,000 technicians worked on the project.
The jet was designed and produced in China and made with resources from around the world. It is an achievement in global cooperation, said Wu.
The C919 incorporates parts from over 30 global suppliers such as Honeywell International Inc. Its engines were made by a joint venture between General Electric and Safran Aircraft Engines.
Both Airbus andBoeinghave assembly plants in China considering the growing demand for new aircraft.
Airbushaddelivered 153 aircraft to Chinese operators in 2016, its seventh consecutive year of more than 100 deliveries, AirbusChina said earlier this year.
A recent Boeing forecast saidthat China will need 6,810 new aircraft in the next 20 years at an estimated cost of USD one trillion.
By the end of 2016, 21 customers had placed orders for more than 500 C919 aircraft, and COMAC expects to sell at least 2,000.