Xi is due to arrive in the tiny English-speaking country off the coast of Venezuela at around 2130 GMT, kicking off a trip that will take him to Costa Rica and Mexico, before a June 7-8 summit with US President Barack Obama.
China's trade ties with Latin America have soared in recent years as the world's second biggest economy taps into the region's mineral and oil wealth to fuel growth.
Xi -- who took office in March in a once-in-a-decade power transfer in Communist-ruled Beijing -- said ahead of the trip he had "full confidence in the prospects of China-Latin America relations."
While there is "a vast ocean between China and Latin America, our hearts are closely linked," Xi told regional media outlets in a joint written interview, according to a transcript by Chinese state news agency Xinhua.
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Tomorrow, Xi is to meet with Prime Minister Kamla Persad-Bissessar and other senior Trinidad and Tobago officials, as well as the leaders of Antigua and Barbuda, the Bahamas, Barbados, Dominica, Granada, Guyana, Jamaica and Suriname.
"Trinidad and Tobago is in an ideal position to facilitate deepened relations between China and the Caribbean region," the Caribbean country's foreign minister Winston Dookeran in an interview with Xinhua.
In a sign of China's growing presence, the Asian giant is overtaking the 27-nation European Union to become Latin America's second largest source of imports, according to the UN's Economic Commission for Latin America and the Caribbean (ECLAC).
Brazil and Mexico, Latin America's first and second biggest economies, respectively, are the top two markets for China in the region.