Chinese herbal compound may fight chronic pain

A compound found in a plant used for centuries in China as a pain reliever may be effective in treating low-level chronic pain, according to new research.
The key pain-relieving ingredient is a compound known as dehydrocorybulbine (DHCB) found in the roots of the flowering plant Corydalis, a member of the poppy family.
"Our study reports the discovery of a new natural product that can relieve pain," said Olivier Civelli of the University of California, Irvine.
"This analgesic acts in animal assays against the three types of pain that afflict humans, including acute, inflammatory, and neuropathic or chronic pain," Civelli said.

Civelli, along with Xinmiao Liang, made the discovery as part of the "herbalome" project, an effort to catalogue all of the chemical components of traditional Chinese medicine.
The Corydalis plants that were the focus of the new study grow mainly in central eastern China, where underground tubers are harvested, ground, and boiled in hot vinegar.

Those concoctions are often prescribed to treat pain, including headaches and back pain.
The researchers went looking for compounds in Corydalis that appeared likely to act in a manner similar to morphine.
"We landed on DHCB but rapidly found that it acts not through the morphine receptor but through other receptors, in particular one that binds dopamine," Civelli said.

The discovery adds to earlier evidence showing that the dopamine D2 receptor plays a role in pain sensation.
While Corydalis extracts or isolated DHCB work against all types of pain, they hold special promise for those who suffer with persistent, low-level chronic pain.
For one thing, DHCB doesn't appear to lose effectiveness with time in the way that traditional opiate drugs do.
"We have pain medication for inflammatory pain, such as aspirin or acetaminophen. We do not have good medications for chronic pain. DHCB may not be able to relieve strong chronic pain, but may be used for low-level chronic pain," said Civelli.

The study was published in the journal Current Biology.