Chopra is a two-time winner on the PGA Tour, while the two others are amateur Sahith Theegala and professional Aaron Rai, a winner on the European Challenge Tour.
All three came through the US Open qualifiers at various venues. While Theegala, now an American, has Indian parents, who went over years ago, Rai's parents, also of Indian origin, arrived into England via Kenya, where they have shifted.
Lahiri will be missing his second successive Major after 10 straight appearances at Majors going back to the 2014 British Open.
Amateur Theegala is paired with Daniel Miernicki and Tyler Light. Both Chopra and Rai have also played in Hero Indian Open in recent past.
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The good news for the golfers is that after concerns expressed by some players that Erin Hills' thick seedhead fescue was too penalizing, there were reports that they have been cut back on four holes.
Other big stars expected to contend over the weekend are world No. 2 Rory McIlroy, also back from a injury, Jordan Spieth, Jason Day, Jon Rahm, Hideki Matsuyama, Justin Rose, Sergio Garcia, Rickie Fowler and Henrik Stenson.
But one stat that will stay uppermost in the minds of all will be that the last Major champions have been first-timers, who had never won a Major before.
That could well mean a fairy-tale story for Mickelson who needs a US Open to complete a career slam and has six second places.