Colfer will be playing the son of Wendie Malick's character Victoria Chase, according to E! online.
The actor's appearance in the TV Land series is slated to shoot next week, to air later this year.
'Hot in Cleveland' has attracted a slew of high-profile guest stars over the last year.
Jason Priestley, Shirley Jones, William Shatner and Jesse Tyler Ferguson have all recently shot cameos for the programme.
'Hot in Cleveland' is currently airing its fifth season in the US on TV Land.