The 'Anchorman 2' star and the musician, who have a two-year-old daughter together, tied the knot in a private ceremony in LA, reported People magazine.
No further details about the nuptials have been revealed yet.
Applegate, 41, began dating 43-year-old LeNoble in 2008, soon after splitting from first husband Johnathon Schaech.
They got engaged on Valentine's Day 2010 and welcomed their daughter, Sadie, into the world the following January.