A 14-man squad departed Wednesday for Harare to play a two-week series that also involves South Africa -- Australia's first international commitment since the ICC World T20 in Bangladesh more than four months ago.
"I think it will be a tough series. It's not a token tour, it's about winning," said Clarke.
Several key players are absent, including injured all-rounder Shane Watson, fast bowler Ryan Harris and father-to-be David Warner.
This has opened the door for the likes of Phil Hughes, Mitch Marsh, Ben Cutting and Kane Richardson to stake their claim to a regular first-team place.
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"Obviously it is unfortunate that we have a few injuries, but it's exciting for people like Mitch Marsh; Phil Hughes gets an opportunity, as does Kane Richardson and Ben Cutting," he said.
"It's a good chance for them to grab their opportunity. The reason you train so hard and perform so well in first-class cricket is to represent Australia, so when you get a chance you have to make the most of it."
But Clarke also denied the players would be treating it as a try-out for the World Cup, to be hosted by Australia and New Zealand in February-March next year.