The 82-year-old actor's wife has enetred into rehab for for anxiety and depression, reported Sun Online.
Ex-TV news anchor Ruiz, 47, has left their home in California, for a clinic in Arizona, where she is set to stay for weeks.
She was last seen in a US TV reality series called 'Mrs Eastwood and Company'.
Eastwood has a 16-year-old daughter, Morgan, with Ruiz.