The former secretary of state announced the new partnership at New York University between the Clinton Foundation and the Gates Foundation.
The project will collect and review data on the progress of women since the 1995 United Nations Beijing conference that Clinton addressed as first lady.
The potential 2016 Democratic presidential candidate is starting the project as part of her "No Ceilings" initiative that aims to empower women in the 21st century.
Clinton says progress has been made but there's a lack of data on what needs to be done to promote female participation in education, politics and the economy around the world.