Clinton -- a celebrity former secretary of state, first lady and New York senator -- who is bidding to become America's first female president, is head-and-shoulders above her 2016 Democratic party rivals according to a Quinnipiac University poll.
She has the backing of 60 per cent of Democrats, according to the survey, with her nearest potential rival, Vice President Joe Biden trailing on 10 percent.
At first blush, that would appear to be superb news for Clinton supporters, who were shocked to lose the party nomination to Barack Obama in 2008.
Perhaps more concerning for Clintonites will be Quinnipiac's finding that more than half of all voters polled say the 67-year-old is not trustworthy.
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Republican party operatives have already launched a massive campaign to undercut Clinton's appeal by painting her as out of touch, manipulative and not to be trusted.
The scandals and pseudo-scandals of her husband Bill Clinton's tenure in the White House have been restated, along with allegations about her use of a private email server, her handling of the murder of a US diplomat in Libya and foreign donations to the Clinton family foundation.
The fight for the Republican nomination is a much more closely-fought affair. Several candidates from across the party's conservative and religious spectra are vying for the lead.
Florida Senator Marco Rubio, the son of Cuban immigrants, garners 15 percent of support from those polled, ahead of Jeb Bush, who is within the margin of error at 13 percent.
The youthful but relatively inexperienced Rubio launched his campaign earlier this month, calling for a new era of American leadership that is not "stuck in the 20th century."
"This is the kind of survey that shoots adrenaline into a campaign," said Quinnipiac's Tim Malloy.