Clinton grew up in Illinois and her career spent working on behalf of children and families has taken her from Massachusetts to Washington, DC, Arkansas and New York.
However, it was the voters of New York who elected her to serve as their first female Senator.
In her launch speech at the Franklin D Roosevelt Four Freedoms Park in New York City, Clinton will lay out her view of the challenges facing this country and her vision and ideas for taking the country forward, campaign officials said.
After her launch, she will travel to all four early primary states. She will be in Iowa on June 13 and 14, in New Hampshire on June 15, in South Carolina on June 17 and in Nevada on June 18.
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This early state schedule reflects Clinton's plan to work for and earn every vote.
In Iowa, no Democratic candidate for president has ever received more than 50 per cent of the caucus vote unless they were a sitting President or Vice-President or an incumbent Iowa Senator.
Even running unopposed in 2012 as the incumbent president, Barack Obama received around 80 per cent of the primary vote.
In a statement, Republican National Committee chairman Reince Priebus said Clinton's campaign has been mired in scandals regarding the Clinton Foundation's foreign donors and her secret email server.
"After dodging questions for months, she should take this opportunity to finally come clean and discuss the issues important to everyday Americans," Priebus said.
"I'm running for president so that I can fight for those families. Because when families are strong, and when children have the opportunity to live up to their God-given potential, that's When America is strong," she said.
Clinton is seeking a Democratic presidential nomination to run for the White House in 2016. If elected, she would be the first woman president of the United States.
This is her second presidential bid. In 2008, she lost in the Democratic Party primaries to current US President Barack Obama.