The Democrat Clinton lost last month's presidential election to Republican Donald Trump in a shock upset, with several Trump critics arguing that the prominence of fake articles shared on Facebook and other social media may have affected the outcome.
The phenomenon nearly turned deadly this week when a rifle-wielding man entered a pizza restaurant in Washington saying he wanted to investigate a fake news story that wrongly stated the Comet Ping Pong restaurant was a center for child abduction linked to Clinton and a top advisor.
"This isn't about politics, or partisanship. Lives are at risk," she said as she blasted "the epidemic of malicious fake news and false propaganda that flooded social media over the past year."
The "danger" must be addressed quickly, she stressed. "It's imperative that leaders from the private sector and the public sector step up to protect our democracy and innocent lives."
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Clinton's remarks were part of her second public address since her concession speech the day after the election.
"But after a few weeks of taking selfies in the woods, I thought it would be a good idea to come out."
Afterward Clinton ignored reporters' questions about whether fake news stories had cost her the election.
The "pizzagate" story that Clinton referred to was widely shared before the November 8 vote.
No one was injured when 28-year-old Edgar Maddison Welch strode into Comet Ping Pong, packed with families on a Sunday afternoon, and fired off a round from his AR-15.
But it raised to a new level the danger of the profusion of false news stories and rumours spread over the internet and in social media, much of it aimed at fortifying the views of various political and social groups.
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