Owen, 47, will interview Rwanda's first ever Olympic mountain biker Adrien Niyonshuti, as part of Playing The Games, a two-week event taking place in the capital during the summer sporting spectacular, reported Daily Express.
Funnyman Fry, an Olympic ambassador, will question American track and field gold medallist Edwin Moses, and Ethiopian long-distance runner Haile Gebrselassie.
The event kicks off at the Criterion Theatre in the capital's West End on July 26, a day before the Olympics opening ceremony.