The Oscar-winning director had voiced his concern about Hollywood slipping into a "witch-hunt" culture in the aftermath of Harvey Weinstein scandal where multiple women accused the producer of sexual misconduct.
"The reality is it's not a witch hunt to these women who were trapped in a hotel room and told they were going to get a part and then suddenly here comes Harvey Weinstein in his birthday suit. That's an assault," said Clooney, without naming the filmmaker, according to The Hollywood Reporter.
Clooney said it was "infuriating" for him to read stories about reporters who investigated the scandal but did not print them for years.
"Why didn't you print that story? I would have liked to [have] seen it. And I would like to know who brought actresses up to Harvey Weinstein's room and then left. I'd like to know that," said Clooney.
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The actor-director hoped that the scandal acts as a "watershed moment" for society where women feel safe enough to talk about sexual harassment.
"If we can get to that point then we actually succeeded. This thing won't end up just being Harvey Weinstein jokes in three months," he added.