Invented in the United States as a tonic drink in the late 19th century, Coca-Cola is a triumph of modern-day marketing, with its contoured bottle one of the most widely recognised global brands.
In 2011, the company introduced a flat surfaced bottle but European Union authorities rejected its trade mark request because they said the new design lacked any "distinctive character."
The General Court of the EU, the bloc's second highest court, ruling on a company appeal, said there was no reason to change that view, with the new design simply a variant of its predecessor.
"In those circumstances, the General Court dismisses in its entirety the action brought by Coca-Cola."
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The judgment features drawings of the new Coke bottle from the side, the top, and at a forward-leaning angle.
Coca-Cola can in theory appeal to the European Court of Justice, the EU's highest court.
There was no immediate reaction from the company.