Only two positive cases, both Kenyans, have been reported at the worlds in the Chinese capital, but the IAAF found itself mired in allegations of doping in the build-up to the championships.
Media reports claimed that data from 12,000 blood tests between 2001 and 2012 had revealed an "extraordinary extent of cheating" and that more than 50 Olympic and world gold medals during that period could be tainted by drug use.
The allegations by the Sunday Times and German broadcaster ARD triggered lurid headlines likening athletics to cycling, whose dark history of doping scandals culminated in disgraced American Lance Armstrong being stripped of his seven Tour de France titles.
Coe, a two-time Olympic 1500m champion, again defended his sport on Sunday.
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"It is ostensibly a clean sport, we have our challenges... And no one would deny that," Coe said.
"It's a global challenge that every sport faces, but there is not anybody of significance in my sport that doesn't have a non-negotiable view about the importance of maintaining a clean sport.
"Can it be cleaner? I hope so. Are there things we can do differently in future? I dare say so.
"Can we do more? Almost certainly, but that's the human condition."
One of the key points of Coe's manifesto to become IAAF president was his desire to establish an independent anti-doping agency, moving away from links with the World Anti-Doping Agency (WADA).