The duo will appear in separate episodes of the CBS sitcom and both instalments will air next year, reported Entertainment Weekly.
D'Angelo will play the ex-wife of Christy Plunkett's (Anna Faris) father Alvin Biletnikoff (Kevin Pollak).
Hanks's guest appearance sees him playing a love interest for Christy, whose plan for their first date goes horribly wrong.
The actor has most recently been seen in the Emmy-winning FX drama series 'Fargo' as Officer Gus Grimly. He has also had memorable roles in 'Dexter' and 'Mad Men'.
'Mom' returns to CBS in the US on October 30.