The collision involving the North Central Texas College team happened at around 9 p.M. (local time) yesterday on Interstate 35 south of Davis, which is about 70 miles (113 kilometers) south of Oklahoma City and 60 miles (96 kilometers) north of Gainesville, Texas, where the school is located.
The team was heading home from a scrimmage earlier yesterday against Southern Nazarene University, in Bethany.
Oklahoma Highway Patrol Capt. Ronnie Hampton said three young women from the team died at the scene, and a fourth woman died at a hospital in nearby Sulphur, the Oklahoman newspaper reported.
Hampton said both drivers will undergo standard toxicology tests. He said details of the crash were still not known but "something happened to cause (the semi-tractor driver) to depart the roadway and impact the other vehicle."
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He said the accident will remain under investigation for several weeks.
Hampton said the semi crossed the median and veered into the southbound lanes, hitting the bus.
The front end of the team van was virtually untouched, but the sides of the vehicle were heavily damaged. Troopers and witnesses said the driver's side of the van sustained the worst damage.
A posting on the North Central Texas College Facebook page reads: "We ask for your prayers at this time for our softball team. Their bus has been involved in an accident in Oklahoma.