The BAFTA award winner had been battling cancer for years and in April 2014 revealed she was receiving treatment for lung cancer, reported Independent.
In a statement Aherne's publicist Neil Reading said: "Caroline Aherne has sadly passed away, after a brave battle with cancer. The Bafta award-winning writer and comedy actor died earlier today at her home in Timperley, Greater Manchester. She was 52. The family ask for privacy at this very sad time."
Born in London, Aherne was raised by Irish parents in Manchester with her brother Mark. Both Aherne and Mark battled retinoblastoma, a rare form of cancer in the eye, during childhood, which left her partially sighted in one eye.
Aherne gained greater recognition in 1994, when her creation Mrs Merton was given her own mock talk show "The Mrs Merton Show".
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Alongside Craig Cash, Aherne wrote and starred in sitcom "The Royle Family", which ran for three series from 1998 to 2000 and spawned four Christmas specials, the last being in 2012.
On Twitter actor and writer Mark Gatiss wrote: "Awful news about Caroline Aherne. So gifted."
"Little Britain" star David Walliams added, "Absolutely devastating news about Caroline Aherne. A true comedy genius, her work was equally funny & touching.