During a five-decade career, he drew for DC, Marvel and others, and was most notable for co-creating the Silver Age version of The Flash and redesigning Batman's look in the 1960s, reported Digital Spy.
Infantino, who was born and raised in New York City, was appointed editorial director of DC in the late 1960s, bringing Jack Kirby to the company in 1970 from Marvel.
He also served as DC's publisher for five years during the 1970s, and went on to work on the first DC/Marvel crossover title Superman vs The Amazing Spider-Man: The Battle of the Century.
DC Entertainment's president Diane Nelson led tributes to Infantino, saying, "The entire DC Entertainment family is saddened by the loss of Carmine Infantino. His contributions to the comics industry and to DC Comics in particular are immense and impossible to quantify.
More From This Section
"Our thoughts are with his family, friends and fans during this difficult time."
Comic artist Jim Lee described Infantino as "a legend", saying, "His influence, reach and impact is humbling and will always live on."