While Pakistan failed to buck the trend against the defending champions for the sixth time, Mahendra Singh Dhoni's men will hope that they turn fourth time lucky after losing to South Africa on three previous editions at the mega event in 1992, 1999 and 2011.
Whether it is Peter Kirsten in '92, Jacques Kallis in '99 or Kallis and AB de Villiers in 2011, India have always found a Protea batsman, who had turned out to be a thorn in the flesh for them.
Although a group league match in this tournament is of little consequence but the winner of this game might just go a long way in clinching the top spot in group B, considering that the other teams are just not world beaters.
So there's a few things that will be at stake and teams have a lot to play for.
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As the two teams clash at the Melbourne Cricket Ground (MCG), South Africa under De Villiers will certainly start as clear favourites against a young bunch of bravehearts led by Dhoni.
While South Africa were a bit patchy in their 62-run win against Zimbabwe, JP Duminy and David Miller's magnificent late blitz turned the course after the minnows dominated the better part of the match.
As South African captain Graeme Smith has aptly pointed out that it will be a battle between India's famed batsmen and South Africa's world class pace attack, the inexperienced Indian bowling will also be put to Test against a quality batting line up led by their talismanic captain, who recently scored the fastest ODI century in just 32 balls.
An attack led by world's finest fast bowling pair in Dale Steyn and Morne Morkel is not an easy proposition on any track in the world, let alone the MCG, where one can expect even bounce.