President Daniel Ortega and Chinese-firm HKND are scheduled to inaugurate the canal in a ceremony in the capital Managua.
The project intends to open up a lucrative trans-ocean shipping route to rival the Panama canal further south. It could be a major financial boon for the Central American country.
Some farmers and native peoples living on the route oppose the project that will disrupt life along a 280-kilometer long (175-mile) corridor. The canal itself will be between 230 and 520 meters wide (750-1700 feet).
Congress passed a law in 2013 giving Wang hiring and land expropriating powers and exempted his company from local tax and commercial regulations.
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The contract conditions, which also allow HKND to operate the canal for 100 years, have drawn criticism and from some in the political and business community.
Environmentalists have warned the canal could destroy sensitive habitats and cloud Lake Nicaragua's waters. The area is also susceptible to earthquakes, scientists have said.
The company is expected to employ 50,000 workers over five years of building work.
The canal will then run across Lake Nicaragua, through rainforest and at least 40 villages before terminating at the mouth of river Punta Gorda in the southern Caribbean.
A canal through Nicaragua has long been considered but was only thought to be financially viable in recent years.