David Neilson and Julie Hesmondhalgh, who played Roy and Hayley Cropper in the soap opera, were awarded the Best Actor and Best Actress title respectively at the ceremony, reported Daily Mirror.
In addition, they also scored Best Dramatic Performance (Neilson), Best On-Screen Partnership, Best Storyline for Hayley's cancer and Best Single Episode for Hayley's death.
The show's other win included Outstanding Achievement for Helen Worth, who has played Gail McIntyre for 40 years, Best Comedy Performance for Simon Gregson, who plays Steve McDonald and Sexiest Female went to Michelle Keegan for the sixth year running.
'EastEnders' won two awards, including Best Newcomer for Maddy Hill. The actress joined the soap as Nancy Carter earlier this year.
'Emmerdale' picked up one award for its storm and siege episode in the Spectacular Scene of the Year category.