Rula Ghani shocked Afghan observers earlier this year when she appeared with her husband during the country's presidential campaign, a rare example of a political wife sharing the spotlight.
Now the Lebanese-American of Christian heritage is set to carve out a role for herself as the patriarchal and deeply Muslim nation's first high-profile first lady.
In an interview with AFP at the presidential palace, Ghani, who speaks five languages, reminisced about her time as a student at the prestigious Sciences Po university in Paris which she attended during the late 1960s.
"When issues began to arise around the veil and hijab in France, I was a little shocked, people seem to not have a very long memory."
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Wearing the full veil in public was banned by French law in 2011, igniting a fierce debate over the value of religious freedom against social cohesion.
Ghani said she supported the ban.
"Regarding the French law against the niqab and burqa which prevent women from being able to move freely and see, because the niqab is a bit like blinders, I am in full agreement with the government of France," Ghani told AFP.
Karzai came to power after a US-led coalition toppled the hardline Taliban government that banned women from leaving their homes without male guardians.
Ghani admits she is still trying to define her role, but hopes that by the end of her husband's five-year term, "men in Afghanistan will be more inclined to recognise whatever role their wives take".
"In one word, more respect," she said.