His studio said today that Yanase died at a Tokyo hotel early Sunday. He had been treated for liver cancer since August.
Anpanman is a superhero with the head made of anpan, or bread filled with red bean paste, a typical snack in Japan.
The round-faced, smiley hero, clad in a red suit and long cape, became hugely popular in a picture book series that started in 1969. The Anpanman television cartoon series started in 1988, and has spread to the rest of Asia.