Medicines containing tetrahydrocannabinol (THC), the plant's main psychoactive ingredient, can now be prescribed by doctors to ease health problems associated with cancer, multiple sclerosis, epilepsy and AIDS, the regulation says.
The drugs can be prescribed only for up to 30 days while the overall quantity for the period cannot exceed 7.5 grams. Other marijuana use remains illegal under Croatian law.
The issue came into public focus in the European Union member-state a year ago after a man in a village near Rijeka, a northern city on the Adriatic coast, was detained for growing cannabis plants in his garden.
His case encouraged several patient and doctor associations to publicly speak about the use of such oil and other marijuana-derived products in helping to treat certain diseases.
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Earlier this year the health ministry set up an expert commission to review the issue, upon whose recommendations and a public debate the regulation was drawn up.
Until now, cannabis oil has been available on the Croatian black market for anything between 300 to 600 euros (USD 343- USD 686) for 10 grams.