The meeting which is also seen as a last ditch effort to resolve the differences before India gets into the election mode where the manoeuvring of decisions regarding the pact will become difficult.
The high-level meeting between Commerce and Industry Minister Anand Sharma and EU Trade Commissioner Karl De Gucht in the EU headquarters will focus on narrowing down the differences, including hiking FDI cap in insurance sector by India, duty cuts both in automobile as well as in wines and spirits sector.
"There are several issues over which there are wide differences and both sides will try to resolve them amicably to make progress on the much-awaited Bilateral Trade and Investment Agreement (BTIA)," the official said.
The meeting also comes within days of India reaching out to Germany, a key member of the 27-nation European bloc, in a big way on the issue with Prime Minister Manmohan Singh seeking a "strong political thrust" from German Chancellor Angela Merkel on inking of the agreement.
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India and the 27-nation bloc are negotiating the BTIA since June 2007 and have missed several deadlines to conclude the talks due to differences among the two sides on the level of opening up of the markets.
Already 16 rounds of negotiations have been completed but still both the sides are engaged to bridge the gap in matters such as tax issues in automobiles, dairy products and movement of professionals across borders.
The EU wants hike in the FDI limit in the insurance sector to 49 per cent from the current 26 per cent, the Bill for which is pending with Parliament.
In pharma, the EU has been pushing for rights to seize drugs transiting through its territory in case its custom authorities suspect intellectual property violation, a demand which India has refused to give.
The two-way trade stood at USD 91.3 billion in 2010-11.