No injuries were immediately reported and no evacuations were ordered.
The train derailed today at about 6:40 am near the Rhode Island Avenue Metro station and one of the derailed cars is leaking sodium hydroxide, which is used to produce various household products including soap and detergents, CSX spokeswoman Kristin Seay said.
Sodium hydroxide is a highly corrosive chemical that can irritate and burn the skin and eyes. CSX says it is working with first responders to contain the chemical.
Chris Nellum said he lives nearby and his window looks directly over the tracks.
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"I thought it was like a semi-truck coming toward the building and when I looked out the window, I saw cars piling up," said Nellum, who had just moved in the night before. "So I'm not even used to hearing trains. It was jarring."
Part of Rhode Island Avenue was closed in both directions. Nellum said his girlfriend tried to leave the area and was told to stay put, but she eventually found a way out. "She's an environmentalist so she is very concerned about whatever is leaking," he said.
The CSX train had three locomotives and 175 cars, including 94 that were loaded with mixed freight, and 81 that were empty.