The shortage of buses on the island nation has caused trucks to be used to carry passengers, in conditions that are often unsafe and have caused frequent accidents, particularly in rural areas.
"There is a preliminary total of 13 dead and 20 injured this morning from a traffic accident on the Camaguey-Santa Cruz del Sur highway, in which a truck outfitted to transport people turned over," the AIN news agency said.
More than 5,300 traffic accidents occurred in Cuba during the first half of 2015, slightly lower than during the same period in 2014.
In total, 346 people have been reported killed in accidents this year.