The 39-year-old British actor, who was in New York, took some time off to visit the store, reported Entertainment Weekly.
"So, the Doctor just came in for a quick visit," JHU Comic Books posted on its social media accounts, alongside a photo of Cumberbatch and the store's manager.
Marvel Entertainment also posted a picture of "The Imitation Game" actor holding a Doctor Strange comic book.
Director Scott Derrickson too shared an image from the shop. "That's a wrap," he wrote in the caption.
"Doctor Strange" will hit the theaters on November 4.