The show's creator David S Goyer will step down as showrunner but will continue to serve as executive producer, according to the Hollywood Reporter.
Former 'X-Files' and 'Breaking Bad' writer John Shiban will take over the reins from season three, as Goyer focuses on movie projects including 'The Breach'.
"I'm very proud of this modern take on the endlessly fascinating Leonardo da Vinci. Everyone from the writers, directors, cast and all the crew have been invaluable and will continue to be for what we have ahead," Goyer said.
Tom Riley, Laura Haddock, Elliot Cowan, Lara Pulver and Blake Ritson are all due to return to the series, which follows the life of a young Leonardo da Vinci.