The "Man of Steel" writer said he intends to bring it back in a few years' time when Leonardo da Vinci is over a decade older, reported Digital Spy.
"There's a possibility we could do a fourth season in a couple of years. There's an idea that takes place 15 years later.
"Say we did it four or five years later, it would be a self-contained eight-episode thing. We may still do that, as it takes place during the Bonfire of the Vanities."
However, Goyer also reassured fans of the show that it will definitely have a satisfying ending in case it doesn't come back.
The historical fantasy drama stars Tom Riley in a fictional version of da Vinci's early life. Shot in Wales, its 10-episode third and final season will be made available in full online via Stars in the US on October 24.
The final season will launch in the UK on FOX from October 25.