The Puerto Rican superstar will be joined by singer- songwriter Luis Fonsi on the stage, reported Billboard.
The ceremony will take place at the University of Miami's Watsco Center on April 27, where the duo will be present for the worldwide television premiere of their monster hit "Despacito".
Yankee and Fonsi recently dropped a remix version featuring Justin Bieber, who sang Spanish lyrics for the first time in his music career.
Mexican actress Kate del Castillo, from the Netflix series "Ingobernable" and Puerto Rican actor and singer Carlos Ponce will host the awards ceremony.