The 19-year-old actress said that those who complained about the photo used for the campaign - in which she posed with a bottle of Jacob's Oh, Lola! perfume between her legs - were reading too much into the image, reported Digital Spy online.
"If you want to read something into a perfume bottle, then I guess you can. But it's also like, 'Why are you making it about that, you creep?'" she said.
The advertisement was banned in the UK by the Advertising Standards Authority over two years ago, after it was deemed "sexually provocative" and "irresponsible".
Four complainants added that the image of Fanning - then aged 17 - "could be seen to sexualize a child" as she "looked under the age of 16".
"I love Marc and trust him. We just laughed about it," Fanning added.