Thousands of followers and fans of the Tibetan spiritual leader are to attend events in Anaheim and at the University of Irvine, including on his actual birthday tomorrow.
"This milestone occasion is a joyous opportunity for people to come together in celebration of His Holiness' life and achievements," said Venerable Lama Tenzin Dhonden, founder of the non-profit Friends of the Dalai Lama.
"On this very special birthday we will have a chance to celebrate his accomplishments in many areas and hear his exciting view for the years to come."
Tomorrow, the Tibetan religious figurehead will discuss climate change and "wisdom, vision and experience," including with other Nobel laureates, while on Tuesday events wrap up with a session on youth leadership.
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The Dalai Lama already marked his official 80th birthday last month -- on June 21 according to the Tibetan lunar calendar -- in Dharamsala, his hometown in exile in India.
China accuses the Dalai Lama of trying to split Tibet from the rest of China and has called him a "wolf in sheep's clothing."
But he remains the most powerful rallying point for Tibetans, both in exile and in their homeland.
Not everyone is celebrating his birthday in California: protests are expected by Shugden Buddhists, who revere a deity denounced since 1996 by the Dalai Lama -- whom they accuse of religious persecution.
"We will be loudly and vividly protesting outside all three days of the Dalai Lama's events in Anaheim and at UC Irvine," spokeswoman Rachael Jeffrey told AFP, saying hundreds of Buddhist demonstrators were expected to turn out.
Any profits from the three days will go to charities chosen by the Dalai Lama.