The fantasy-thriller is based on the cult novel by Joe Hill and is directed by Alexandre Aja.
Radcliffe will play Ig Perrish in the movie, who is accused of violently raping and killing his girlfriend. Ig awakes one morning to find horns growing from his head and diabolical powers at his command.
"He's a great character. It's nice to play a real sort of anti-hero who does a few genuinely nasty things to people," Radcliffe told Total Film in an interview.
"Alex Aja is one of the most special directors, I think. The way he puts scenes together is beautiful and visually stunning," he said.