The Oscar-winner has done films on drug addicts, thrillers, real-life stories and a film on Mumbai slums.
Speaking at the BAFTA awards, Boyle said, "We always try to do films that are slightly different than the last one, and that's partly trying to chase this dream of getting back to that place of not knowing what you're doing.
"You're trying to get back to an innocence where there is something wonderful about having to research a particular genre," he added.
"It's not really about a stolen painting. It's actually about stolen memories. It's not really about amnesia. It's actually about forgetting as a behavioral choice. And it's not really about a femme fatale in the classical sense."
"Trance" will release in theatres on April 5.