The 82-year-old actor had earlier said he would no longer make public appearances from January next year due to health issues.
The announcement was made on the Facebook page, Love of Sci-Fi convention, which will take place in December.
"It is with a heavy heart that we have to announce that Dave Prowse will be retiring earlier than anticipated so will not be making any more public appearances... Due to ill health his doctors have advised it's best to call it a day," the post read.
The customers who had purchased photos with the actor are being refunded. They even apologised to the fans who had planned to come and see him one last time.
The news comes after Prowse announced he was retiring from international fan conventions in October last year.