The famous tome on evolution that was first published in 1859 has been hailed as "a book which has changed the way we think about everything."
The biology bombshell, which founded evolutionary biology, was the undisputed winner with over a quarter of the votes submitted by the public.
With titles in the running including 'A Vindication of the Rights of Woman' by Mary Wollstonecraft, George Orwell's novel 'Nineteen Eighty-Four', and Adam Smith's 'The Wealth of Nations', Darwin's explanation of his theory of evolution was the public's overwhelming favourite, with 26 per cent of the vote, orginisers said.
On the Origin of Species was followed in the public vote by 'The Communist Manifesto' and 'The Complete Works of Shakespeare', with Plato's 'The Republic' fourth and Immanuel Kant's 'Critique of Pure Reason' fifth, The Guardian reported.
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"I am gratified that the Critique of Pure Reason, which must be surely one of the most difficult works of philosophy ever written, should have been chosen as among the most influential of all academic books," said Philosopher Roger Scruton of the 18th-century text.
The poll took place on the Academic Book Week website and kicked off a weeklong event hosted by The Academic Book of the Future project. The project looks at how scholarly work in the arts and humanities will be produced, read, and preserved in coming years.