The 43-year-old actor and comedian will be hosting "SNL" in what is sure to be an emotionally charged episode, regardless of the outcome of Tuesday's election.
His musical guests will be legendary hip-hop act A Tribe Called Quest, who will be releasing their first album in 18 years the day before the show, according to The Hollywood Reporter.
Chappelle has rarely made any television or other public appearances in over a decade, ever since he left his own "Chappelle's Show" suddenly in 2005, with that series ending the following year.
He made his film debut in Mel Brooks' "Robin Hood: Men In Tights" and went on to co-write and star in the 1998 drop-out classic "Half-Baked". He also produced and starred in the documentary "Dave Chappelle's Block Party.