Heritage Auctions says Bowie's hair will go on the block yesterday as part of an auction in Beverly Hills, California.
Heritage says the lock comes from a former employee at Madame Tussauds Wax Museum in London. She snipped some of Bowie's hair in the 1980s to create a wig for a wax figure of the singer.
Heritage says she kept it as a souvenir.
The rock superstar died in January at 69 after a battle with liver cancer.