The two actors, who played FBI agents Fox Mulder and Dana Scully in the sci-fi TV series, said they are willing to star in another spin-off of the story, reported the Wrap.
"All the principals are on board," Duchovny said during a panel discussion at a celebration of the 20th anniversary of the series' premiere in New York recently.
"Gillian and I want to do it, so it's really up to Twentieth Century Fox at this point," the actor said.
Anderson told fans that if they want another film they should let their voices be heard.
The first 'X Files' movie released in 1998 and was followed up by 'The X-Files: I Want to Believe' 2008.