Marvel Studios announced that Tennant, 43, will have a recurring role in the limited-run series as Zebediah Killgrave, a villain more commonly known as the Purple Man, reported Entertainment Weekly.
The mind-controlling Killgrave has a connection to superhero-turned-detective Jessica Jones (Krysten Ritter), and throws her life into chaos when he reappears in New York City.
"I'm so honoured and excited by the prospect of David inhabiting this multifaceted character," showrunner Melissa Rosenberg announced.
"He can deliver the most heart-wrenching moment to the driest of lines, and all points in between. He'll make Killgrave a truly original villain."