After rising 1.91 per cent to Rs 1,851.15 in intra-day trade, shares of Lupin succumbed to profit-booking and finally ended at Rs 1,811.10, down 0.29 per cent on BSE.
On the NSE, the stock settled 0.58 per cent lower at Rs 1,806.20.
Lupin replaced private sector electricity producer Tata Power. Shares of Tata Power, however, rose by 3.33 per cent to close the day at Rs 74.55 on the BSE.
Since May 22, when the announcement was made by BSE, shares of Tata Power had lost nearly 5 per cent, while Lupin gained 4.6 per cent.