De Bruyne's injury time contribution earned City a 2-1 home win against Spain's Europa League champions to improve their chances of escaping from Group D and into the last 16.
An open affair at the Etihad Stadium was heading for a draw after Adil Rami's own goal cancelled out Yevhen Konoplyanka's 30th-minute opener for Sevilla, only for De Bruyne to gather a pass from Yaya Toure and slam home with his left foot seconds into stoppage time.
Manchester United, who host City in the Premier League on Sunday, faced a tricky assignment away to CSKA Moscow, their French starlet Anthony Martial firmly leaving his imprint on the encounter.
The 19-year-old was called for handball which led to CSKA taking the lead on 15 minutes, Seydou Doumbia slamming in the rebound after United keeper David de Gea had parried Roman Eremenko's penalty onto the post.
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But the French teenager atoned for his mistake with a fine header after the hour for his first goal in the competition and fifth since his high profile move from Monaco in August.
Ronaldo, the Brazilian 2002 World Cup winner, was in the stands at Parc des Princes to watch the headline tie between PSG and Real.
But despite both clubs deploying their all-time top scorers the game ended goalless, Real legend Cristiano Ronaldo coming as close as anyone to breaking the deadlock in the French capital with a second-half volley that whistled wide.
Both sides remain unbeaten this season and are yet to concede after three games as they sit locked together on seven points at the top of Group A.
In Group C, Diego Simeone's 2014 runners-up Atletico Madrid eased past Astana 4-0 to get their European campaign back on track after a shock defeat to Benfica last time out.
Saul Niguez opened the scoring with a clever backheel before Jackson Martinez scored his first goal at the Vicente Calderon for Atletico to put the hosts well on course for victory. Substitute Oliver Torres added a third after the break before Denis Dedchenko's late own goal rounded off the scoring.