The 41-year-old Mexican-American earned his place in the boxing shrine with a professional career that included 10 world titles in six different weight divisions.
He turned pro after a sparkling amateur career that included an Olympic gold medal.
"Today marks an incredible personal achievement, but it is only the latest milestone that never would have been possible without my family, my friends and, most of all, my fans," De la Hoya said at his induction ceremony yesterday.
Calzaghe, 42, finished a 15-year pro career 46-0 with 32 knockouts and defended his super middleweight crown 21 times. In his final fights at light heavyweight, Calzaghe dispatched Bernard Hopkins and Roy Jones.
Trinidad, 41, finished 42-3 with 35 knockouts, captured the International Boxing Federational welterweight title in his 20th pro fight and made 15 successful title defenses, 12 of them by knockouts. Among his victims were De la Hoya and Pernell Whitaker.