The 73-year-old star, who had one of the most successful collaborations with Scorsese in many films, says "Titanic" star has a similar kind of bond with Scorsese, having worked with him on five movies, according to The Hollywood Reporter.
"Leo loves Marty the way I do, so it's great. I'd love for the three of us to do something," he said.
De Niro also revealed that Scorsese asked him to appear in DiCaprio-starrers "Gangs of New York" and "The Departed" but his scheduling issues got in the way.
The film will hit theatres in 2018.