Officials urged millions of people in the storm's path to seek shelter and brace for a weekend of travel disruptions.
The states most hit by the blizzard were Georgia, North Carolina, Tennessee, Maryland, Virginia, Pennsylvania, New Jersey, New York and Kentucky, in addition to Washington DC, which has declared a "snow emergency."
In Virginia, which has a large Telugu population, media reported several weather-related accidents yesterday. Virginia State Police responded to more than 800 traffic accidents.
A number of temples and other places of worship, including gurdwaras, in the region have opened up to shelter people.
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Up to 85 million people -- about one quarter of the US population -- were in the path of the storm that has iced up much of the East Coast and the Mid-Atlantic.
At least eight people had died by late yesterday, reports said.
Latest estimate suggest more than 120,000 homes have been left without electricity as the storm, dubbed "Snowzilla" by some US media, began dumping several inches of snow across the region.
"We have a forecast that we did not had in 90 years. It has life-and-death implication, and all the residents of the District of Columbia should treat it that way," Washington DC Mayor Miriel E Bowser said.
He said District National Guard has been deployed.
Local governments have deployed hundreds of plows and salt trucks to clear out snow on roads and highways.
With temperatures below the freezing point, people stayed indoors and found shelters to keep warm.
More than 6,000 flights were canceled between yesterday and today and over 4,500 delayed. As a precaution, the public transport system have been shut down in the Washington region.
"The combination of heavy snowfall and strong winds will produce whiteout conditions and extremely dangerous travel," the National Weather Service (NWS) said.
NWS officials said the storm could cause more than USD 1 billion in damage. The blizzard is expected to last about 36 hours and leave more than two feet of snow in some places.
Officials throughout the Mid-Atlantic region warned that it could be days, or even a week, before residents will be able to dig out.