Local sources said about 10 people had been killed in a settling of scores between armed groups last night in the restive Muslim PK5 neighbourhood of the capital Bangui.
The toll had yet to be confirmed by the UN force MINUSCA - which will be alone in facing the militia terrorising civilians now that France is ending its Sangaris operation, begun three years ago to halt mass killings in the former French colony.
"The French army will indeed be less visible but it will be present, active and vigilant. We're proud of Operation Sangaris, so it's out of the question to allow the gains to be put at risk," Le Drian told MPs fearful of renewed violence.
Residents were continuing to flee the area around PK5 today, fearing further bloodshed. A helicopter from the international force circled over the city from dawn, an AFP correspondent said.
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The latest clashes came just after Le Drian arrived yesterday to wind up the mission launched at the end of 2013 to prevent a feared genocide after president Francois Bozize was ousted from power.
The French minister went into talks with the CAR's President Faustin-Archange Touadera, elected early this year once relative calm was restored, and met officials in MINUSCA.
Earlier this month Le Drian told the French parliament that the Sangaris mission, backed by a UN mandate, had been "a success".
"We stopped the mass killings... Allowed a process of intercommunal reconciliation, the reconstitution of the state, a presidential election, and legislative elections," he said.
Prominent CAR politician and former presidential candidate Anicet Georges Dologuele challenged Le Drian's optimism, stating that "Sangaris is pulling out far too early."
"It's always too early," Le Drian countered. "These responsibilities are above all your own.