Typhoon Damrey struck days before Vietnam is set to host the Asia-Pacific Economic Cooperation (APEC) conference in Danang next weekend. It will bring together US President Donald Trump, China's Xi Jinping and Russia's Vladimir Putin, among other leaders.
While Danang itself was spared the worst damage, muddy floodwaters have submerged the hardest-hit provinces and swamped nearby Hoi An, a UNESCO World Heritage Site that was due to host APEC spouses later this week.
Since the storm made landfall on Saturday 69 people have perished in floods, landslides and on capsized boats at sea, while 30 others are still missing, the government said.
UNICEF said at least four children were among the dead, with two others missing and an estimated one million young people affected by one of the worst storms to hit the area in years.
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Authorities warned that raging rivers were filling reservoirs to near-capacity in central and southern provinces, with rain still pelting down in some areas.
Flooding and landslides in northern and central regions killed more than 70 people last month.
In September Typhoon Doksuri tore through central Vietnam, killing 11 people across several provinces.
The country has reported at least 240 people dead or missing in floods and landslides since the beginning of the year.